Crystallin: Difference between revisions

Revision as of 11:15, 5 April 2017

Function

Crystalline is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. α-, β-, γ-, δ-crystalline are named according to the order they are eluted by gel filtration. δ-crystalline is found in avian and reptilian lenses.^[1]

Disease

Several human cataracts have been linked to mutations in γ-D-crystalline.

3D Structures of Crystalline3D Structures of Crystalline

Updated on 05-April-2017

2g98 - hγ-D-crystalline – human
1h4a - hγ-D-crystalline (mutant)
1elp - γ-D-crystalline – bovine
1auw - δ-2-crystalline (mutant) - duck

ReferencesReferences

↑ Basak A, Bateman O, Slingsby C, Pande A, Asherie N, Ogun O, Benedek GB, Pande J. High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract. J Mol Biol. 2003 May 16;328(5):1137-47. PMID:12729747

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

[1] Basak A, Bateman O, Slingsby C, Pande A, Asherie N, Ogun O, Benedek GB, Pande J. High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract. J Mol Biol. 2003 May 16;328(5):1137-47. PMID:12729747

[1]

@@ Line 1: / Line 1: @@
-{{STRUCTURE_2g98|  PDB=2g98  | SIZE=300| SCENE=Crystalline/C/1 |right|CAPTION=human γ-D-crystalline, [[2g98]] }}
+<StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D-crystalline,  [[2g98]]'>
 == Function ==
@@ Line 7: / Line 8: @@
 Several human cataracts have been linked to mutations in γ-D-crystalline.
+</StructureSection>
 == 3D Structures of Crystalline ==