CREB-binding protein: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='' caption='Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions [[3p1c]]'> | |||
[[Image:1kbh.png|left|200px|thumb|Crystal structure of CREB-binding protein bromodomain (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]] | [[Image:1kbh.png|left|200px|thumb|Crystal structure of CREB-binding protein bromodomain (green) complex with nuclear receptor coactivator (grey) [[1kbh]]]] | ||
== Function == | == Function == | ||
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CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73. | CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73. | ||
</StructureSection> | |||
== 3D Structures of CREB-binding protein == | == 3D Structures of CREB-binding protein == | ||
Revision as of 16:33, 31 January 2016
FunctionCREB-binding protein (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. [1] DiseaseMutations in CBP cause Rubinstein-Taybi syndrome.[2] Structural highlightsCBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73. |
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3D Structures of CREB-binding protein3D Structures of CREB-binding protein
Updated on 31-January-2016
ReferencesReferences
- ↑ Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9. PMID:8413673 doi:http://dx.doi.org/10.1038/365855a0
- ↑ Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ, et al.. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature. 1995 Jul 27;376(6538):348-51. PMID:7630403 doi:http://dx.doi.org/10.1038/376348a0