1amh: Difference between revisions

Revision as of 10:26, 2 May 2008

UNCOMPLEXED RAT TRYPSIN MUTANT WITH ASP 189 REPLACED WITH SER (D189S)

OverviewOverview

Structure-based mutational analysis of serine protease specificity has produced a large database of information useful in addressing biological function and in establishing a basis for targeted design efforts. Critical issues examined include the function of water molecules in providing strength and specificity of binding, the extent to which binding subsites are interdependent, and the roles of polypeptide chain flexibility and distal structural elements in contributing to specificity profiles. The studies also provide a foundation for exploring why specificity modification can be either straightforward or complex, depending on the particular system.

About this StructureAbout this Structure

1AMH is a Single protein structure of sequence from Rattus rattus. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of substrate specificity in the serine proteases., Perona JJ, Craik CS, Protein Sci. 1995 Mar;4(3):337-60. PMID:7795518 Page seeded by OCA on Fri May 2 10:26:59 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1amh.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1amh |SIZE=350|CAPTION= <scene name='initialview01'>1amh</scene>, resolution 2.5&Aring;
+The line below this paragraph, containing "STRUCTURE_1amh", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=CAA:Catalytic+Site'>CAA</scene> and <scene name='pdbsite=CAB:Catalytic+Site'>CAB</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1amh|  PDB=1amh  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1amh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amh OCA], [http://www.ebi.ac.uk/pdbsum/1amh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1amh RCSB]</span>
-}}
 '''UNCOMPLEXED RAT TRYPSIN MUTANT WITH ASP 189 REPLACED WITH SER (D189S)'''
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 [[Category: Naray-Szabo, G.]]
 [[Category: Szabo, E.]]
-[[Category: activation domain]]
+[[Category: Activation domain]]
-[[Category: serine protease]]
+[[Category: Serine protease]]
-[[Category: substrate specificity hydrolase]]
+[[Category: Substrate specificity hydrolase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:26:59 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:43:21 2008''