Sandbox 420: Difference between revisions
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==Control of Appetite== | ==Control of Appetite== | ||
CB1 receptors play a significant role in appetite control by regulating food intake, influencing fat accumulation, and altering lipid and glucose metabolism. Activation of CB1, results in the release of hormones that promote hunger and thus stimulate appetite | CB1 receptors play a significant role in appetite control by regulating food intake, influencing fat accumulation, and altering lipid and glucose metabolism. Activation of CB1, results in the release of hormones that promote hunger and thus stimulate appetite <ref name = "food">PMID: 24933167</ref>. CB1 also interacts with the neuropeptides controlling functions of lipid and glucose metabolism. As a result, the endogenous function of CB1 receptors is key to controlling homeostasis in energy balance <ref name="food"/>. Furthermore, hyperactivity of these functions is associated THC use. This function of CB1 receptors may play a key role in the development of obesity treatments. | ||
==Regulation of Anxiety== | ==Regulation of Anxiety== | ||
CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic | CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoid, produces the harmful side effect of extreme anxiety. | ||