1aik: Difference between revisions

Revision as of 10:18, 2 May 2008

HIV GP41 CORE STRUCTURE

OverviewOverview

The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes. Previous studies identified an alpha-helical domain within gp41 composed of a trimer of two interacting peptides. The crystal structure of this complex, composed of the peptides N36 and C34, is a six-helical bundle. Three N36 helices form an interior, parallel coiled-coil trimer, while three C34 helices pack in an oblique, antiparallel manner into highly conserved, hydrophobic grooves on the surface of this trimer. This structure shows striking similarity to the low-pH-induced conformation of influenza hemagglutinin and likely represents the core of fusion-active gp41. Avenues for the design/discovery of small-molecule inhibitors of HIV infection are directly suggested by this structure.

About this StructureAbout this Structure

1AIK is a Protein complex structure of sequences from Human immunodeficiency virus type 1 (isolate hxb2). Full crystallographic information is available from OCA.

ReferenceReference

Core structure of gp41 from the HIV envelope glycoprotein., Chan DC, Fass D, Berger JM, Kim PS, Cell. 1997 Apr 18;89(2):263-73. PMID:9108481 Page seeded by OCA on Fri May 2 10:18:54 2008

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OCA

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 [[Image:1aik.gif|left|200px]]
- {{Structure
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-|GENE= GP41 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human immunodeficiency virus type 1 (isolate HXB2)])
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-}}
 '''HIV GP41 CORE STRUCTURE'''
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 ==Reference==
 Core structure of gp41 from the HIV envelope glycoprotein., Chan DC, Fass D, Berger JM, Kim PS, Cell. 1997 Apr 18;89(2):263-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9108481 9108481]
-[[Category: Human immunodeficiency virus type 1 (isolate hxb2)]]
 [[Category: Protein complex]]
 [[Category: Berger, J M.]]
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 [[Category: Fass, D.]]
 [[Category: Kim, P S.]]
-[[Category: envelope glycoprotein]]
+[[Category: Envelope glycoprotein]]
-[[Category: gp41]]
+[[Category: Gp41]]
-[[Category: hiv]]
+[[Category: Hiv]]
-[[Category: retrovirus]]
+[[Category: Retrovirus]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:18:54 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:40:58 2008''