1ab8: Difference between revisions

Revision as of 10:04, 2 May 2008

RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX

OverviewOverview

Mammalian adenylyl cyclases contain two conserved regions, C1 and C2, which are responsible for forskolin- and G-protein-stimulated catalysis. The structure of the C2 catalytic region of type II rat adenylyl cyclase has an alpha/beta class fold in a wreath-like dimer, which has a central cleft. Two forskolin molecules bind in hydrophobic pockets at the ends of cleft. The central part of the cleft is lined by charged residues implicated in ATP binding. Forskolin appears to activate adenylyl cyclase by promoting the assembly of the active dimer and by direct interaction within the catalytic cleft. Other adenylyl cyclase regulators act at the dimer interface or on a flexible C-terminal region.

About this StructureAbout this Structure

1AB8 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the adenylyl cyclase catalytic core., Zhang G, Liu Y, Ruoho AE, Hurley JH, Nature. 1997 Mar 20;386(6622):247-53. PMID:9069282 Page seeded by OCA on Fri May 2 10:04:12 2008

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OCA

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 [[Image:1ab8.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1ab8 |SIZE=350|CAPTION= <scene name='initialview01'>1ab8</scene>, resolution 2.2&Aring;
+The line below this paragraph, containing "STRUCTURE_1ab8", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=FOK:FORSKOLIN'>FOK</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= PPROEX-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
+-->
-|DOMAIN=
+{{STRUCTURE_1ab8|  PDB=1ab8  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ab8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ab8 OCA], [http://www.ebi.ac.uk/pdbsum/1ab8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ab8 RCSB]</span>
-}}
 '''RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX'''
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 [[Category: Hurley, J H.]]
 [[Category: Zhang, G.]]
-[[Category: adenylyl cyclase]]
+[[Category: Adenylyl cyclase]]
-[[Category: complex (transferase/inhibitor)]]
+[[Category: Lyase]]
-[[Category: lyase]]
+[[Category: Plasmid]]
-[[Category: plasmid]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:04:12 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:36:57 2008''