1a8a: Difference between revisions

Revision as of 09:57, 2 May 2008

RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE

OverviewOverview

Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.

About this StructureAbout this Structure

1A8A is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670 Page seeded by OCA on Fri May 2 09:57:44 2008

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OCA

@@ Line 1: / Line 1: @@
 [[Image:1a8a.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1a8a |SIZE=350|CAPTION= <scene name='initialview01'>1a8a</scene>, resolution 1.9&Aring;
+The line below this paragraph, containing "STRUCTURE_1a8a", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=GSE:Gse+Binding+Site+(Includes+2+Ca+Ions)'>GSE</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GSE:L-ALPHA-GLYCEROPHOSPHORYLSERINE'>GSE</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1a8a|  PDB=1a8a  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8a OCA], [http://www.ebi.ac.uk/pdbsum/1a8a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a8a RCSB]</span>
-}}
 '''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE'''
@@ Line 30: / Line 27: @@
 [[Category: Seaton, B A.]]
 [[Category: Swairjo, M A.]]
-[[Category: calcium binding protein]]
+[[Category: Calcium binding protein]]
-[[Category: membrane binding protein]]
+[[Category: Membrane binding protein]]
-[[Category: phospholipid analog]]
+[[Category: Phospholipid analog]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:57:44 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:35:24 2008''