5epb: Difference between revisions

Revision as of 13:48, 10 December 2016

Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49

Structural highlights

5epb is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Activity:	Adenosinetriphosphatase, with EC number 3.6.1.3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.^[1]

References

↑ Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-72. Epub 2007 Nov 12. PMID:17998543 doi:http://dx.doi.org/10.1073/pnas.0705814104

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OCA

[1] Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-72. Epub 2007 Nov 12. PMID:17998543 doi:http://dx.doi.org/10.1073/pnas.0705814104

[1]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5epb is ON HOLD  until Nov 11 2017
+==Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49==
+<StructureSection load='5epb' size='340' side='right' caption='[[5epb]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Dong, J., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5epb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EPB FirstGlance]. <br>
-Description: Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5QW:~{N}-[(2~{S})-2-MORPHOLIN-4-YLPROPYL]-4-OXIDANYLIDENE-3,5-DIHYDRO-2~{H}-1,5-BENZOTHIAZEPINE-7-CARBOXAMIDE'>5QW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5epb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epb OCA], [http://pdbe.org/5epb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5epb RCSB], [http://www.ebi.ac.uk/pdbsum/5epb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5epb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Adenosinetriphosphatase]]
+[[Category: Caflisch, A]]
 [[Category: Dong, J]]
-[[Category: Caflisch, A]]
+[[Category: Hydrolase inhibitor complex]]
+[[Category: Transferase]]

5epb: Difference between revisions

Revision as of 13:48, 10 December 2016

Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49

Structural highlights

Function

References

Contents

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5epb: Difference between revisions

Revision as of 13:48, 10 December 2016

Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49Crystal structure of the bromodomain of human ATAD2 in complex with Compound 49

Structural highlights

Function

References

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