5eg9: Difference between revisions
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''' | ==The cap binding site of influenza virus protein PB2 as a drug target== | ||
<StructureSection load='5eg9' size='340' side='right' caption='[[5eg9]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5eg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EG9 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eg7|5eg7]], [[5eg8|5eg8]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eg9 OCA], [http://pdbe.org/5eg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eg9 RCSB], [http://www.ebi.ac.uk/pdbsum/5eg9 PDBsum]</span></td></tr> | |||
</table> | |||
[ | == Function == | ||
[[http://www.uniprot.org/uniprot/PB2_I02A6 PB2_I02A6]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Li, K]] | [[Category: Li, K]] | ||
[[Category: Liu, Y]] | |||
[[Category: Luo, M]] | [[Category: Luo, M]] | ||
[[Category: Moura, T Rocha de]] | |||
[[Category: Severin, C]] | |||
[[Category: Zheng, X]] | [[Category: Zheng, X]] | ||
[[Category: | [[Category: Pb2 cap]] | ||
[[Category: | [[Category: Viral protein]] | ||
Revision as of 20:27, 10 February 2016
The cap binding site of influenza virus protein PB2 as a drug targetThe cap binding site of influenza virus protein PB2 as a drug target
Structural highlights
Function[PB2_I02A6] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428] |
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