4zzc: Difference between revisions

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'''Unreleased structure'''


The entry 4zzc is ON HOLD
==The GLIC pentameric Ligand-Gated Ion Channel open form complexed to xenon==
 
<StructureSection load='4zzc' size='340' side='right' caption='[[4zzc]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors: Sauguet, L., Fourati, Z., Prange, T., Delarue, M., Colloc'h, N.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4zzc]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZZC FirstGlance]. <br>
Description: The GLIC pentameric Ligand-Gated Ion Channel open form complexed to xenon
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zzc OCA], [http://pdbe.org/4zzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zzc RCSB], [http://www.ebi.ac.uk/pdbsum/4zzc PDBsum]</span></td></tr>
[[Category: Colloc'H, N]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Delarue, M]]
[[Category: Fourati, Z]]
[[Category: Prange, T]]
[[Category: Prange, T]]
[[Category: Fourati, Z]]
[[Category: Delarue, M]]
[[Category: Sauguet, L]]
[[Category: Sauguet, L]]
[[Category: H, N Colloc]]
[[Category: Membrane protein]]
[[Category: Transport protein]]

Revision as of 18:19, 2 March 2016

The GLIC pentameric Ligand-Gated Ion Channel open form complexed to xenonThe GLIC pentameric Ligand-Gated Ion Channel open form complexed to xenon

Structural highlights

4zzc is a 5 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]

References

  1. ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

4zzc, resolution 3.10Å

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OCA
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