4zt5: Difference between revisions

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'''Unreleased structure'''


The entry 4zt5 is ON HOLD  until Paper Publication
==Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine (Chem 1655)==
 
<StructureSection load='4zt5' size='340' side='right' caption='[[4zt5]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
Authors: Koh, C.-Y., Hol, W.G.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4zt5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZT5 FirstGlance]. <br>
Description: Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine (Chem 1655)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4RN:(2S)-N-(3,5-DICHLOROBENZYL)-N-(1H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-2-METHYLPROPANE-1,3-DIAMINE'>4RN</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
[[Category: Hol, W.G.J]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zt7|4zt7]], [[4zt6|4zt6]], [[4zt4|4zt4]], [[4zt3|4zt3]], [[4zt2|4zt2]]</td></tr>
[[Category: Koh, C.-Y]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zt5 OCA], [http://pdbe.org/4zt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zt5 RCSB], [http://www.ebi.ac.uk/pdbsum/4zt5 PDBsum]</span></td></tr>
</table>
__TOC__
</StructureSection>
[[Category: Methionine--tRNA ligase]]
[[Category: Hol, W G.J]]
[[Category: Koh, C Y]]
[[Category: Aar]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Ligase]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Metr]]
[[Category: Protein-inhibitor complex]]
[[Category: Trypanosoma brucei]]

Revision as of 22:34, 13 May 2016

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine (Chem 1655)Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine (Chem 1655)

Structural highlights

4zt5 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
NonStd Res:
Activity:Methionine--tRNA ligase, with EC number 6.1.1.10
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

4zt5, resolution 2.35Å

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