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==Structures of the human OX1 orexin receptor bound to selective and dual antagonists== | |||
<StructureSection load='4zj8' size='340' side='right' caption='[[4zj8]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zj8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJ8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zjc|4zjc]]</td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zj8 OCA], [http://pdbe.org/4zj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zj8 PDBsum]</span></td></tr> | ||
[[ | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Brautigam, C A]] | |||
[[Category: Clark, L]] | [[Category: Clark, L]] | ||
[[Category: Coleman, P]] | |||
[[Category: Gotter, A L]] | |||
[[Category: Harrell, C M]] | |||
[[Category: Renger, J J]] | |||
[[Category: Rosenbaum, D M]] | |||
[[Category: Shao, Z]] | [[Category: Shao, Z]] | ||
[[Category: Yin, J]] | [[Category: Yin, J]] | ||
[[Category: | [[Category: Orexin]] | ||
[[Category: Sb674042]] | |||
[[Category: Signaling protein]] | |||
[[Category: Suvorexant]] | |||
Revision as of 06:51, 10 March 2016
Structures of the human OX1 orexin receptor bound to selective and dual antagonistsStructures of the human OX1 orexin receptor bound to selective and dual antagonists
Structural highlights
Function[OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). |
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