4yu0: Difference between revisions

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-'''Unreleased structure'''
+==Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution==
+<StructureSection load='4yu0' size='340' side='right' caption='[[4yu0]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
-The entry 4yu0 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yu0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YU0 FirstGlance]. <br>
-Authors: Chebli, M., Salazar, H., Baranovic, J., Carbone, A.L., Ghisi, V., Faelber, K., Lau, A.Y., Daumke, O., Plested, A.J.R.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yu0 OCA], [http://pdbe.org/4yu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yu0 RCSB], [http://www.ebi.ac.uk/pdbsum/4yu0 PDBsum]</span></td></tr>
-Description: Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Ghisi, V]]
+[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
-[[Category: Lau, A.Y]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Baranovic, J]]
+[[Category: Carbone, A L]]
 [[Category: Chebli, M]]
+[[Category: Daumke, O]]
 [[Category: Faelber, K]]
-[[Category: Plested, A.J.R]]
+[[Category: Ghisi, V]]
+[[Category: Lau, A Y]]
+[[Category: Plested, A J.R]]
 [[Category: Salazar, H]]
-[[Category: Daumke, O]]
+[[Category: Ligand-gated ion channel]]
-[[Category: Carbone, A.L]]
+[[Category: Tetramer]]
+[[Category: Transport protein]]