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==Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with 2-({[4-(Trifluoromethoxy)Phenyl]Sulfonyl}Amino)Ethyl Dihydrogen Phosphate (F9F) inhibitor in the alpha site and ammonium ion in the metal coordination site.== | |||
<StructureSection load='4xug' size='340' side='right' caption='[[4xug]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xug]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F9F:2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL+DIHYDROGEN+PHOSPHATE'>F9F</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ht3|4ht3]], [[4hn4|4hn4]], [[4hpj|4hpj]], [[4hpx|4hpx]], [[3pr2|3pr2]], [[2cll|2cll]], [[2cli|2cli]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xug OCA], [http://pdbe.org/4xug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xug RCSB], [http://www.ebi.ac.uk/pdbsum/4xug PDBsum]</span></td></tr> | ||
[[ | </table> | ||
[[ | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. | ||
[[Category: Caulkins, B | __TOC__ | ||
</StructureSection> | |||
[[Category: Tryptophan synthase]] | |||
[[Category: Caulkins, B G]] | |||
[[Category: Dunn, M F]] | |||
[[Category: Fan, L]] | [[Category: Fan, L]] | ||
[[Category: Hilario, E]] | [[Category: Hilario, E]] | ||
[[Category: Mueller, L J]] | |||
[[Category: Niks, D]] | |||
[[Category: Young, R P]] | |||
[[Category: Allosteric enzyme]] | |||
[[Category: Aromatic amino acid biosynthesis]] | |||
[[Category: Carbon-oxygen lyase]] | |||
[[Category: F9f]] | |||
[[Category: Hydro-lyase]] | |||
[[Category: Inhibitor]] | |||
[[Category: Lyase-lyase inhibitor complex]] | |||
[[Category: Pyridoxal phosphate]] | |||
[[Category: Salmonella typhimurium]] | |||
[[Category: Tryptophan biosynthesis]] | |||
Revision as of 05:30, 28 January 2016
Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with 2-({[4-(Trifluoromethoxy)Phenyl]Sulfonyl}Amino)Ethyl Dihydrogen Phosphate (F9F) inhibitor in the alpha site and ammonium ion in the metal coordination site.Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with 2-({[4-(Trifluoromethoxy)Phenyl]Sulfonyl}Amino)Ethyl Dihydrogen Phosphate (F9F) inhibitor in the alpha site and ammonium ion in the metal coordination site.
Structural highlights
Function[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. |
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