2n7b: Difference between revisions
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==NMR structure of human I-type lectin domain-glycan complex== | |||
<StructureSection load='2n7b' size='340' side='right' caption='[[2n7b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n7b]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7B FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0D8:3-AMINOPROPAN-1-OL'>0D8</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=G6S:D-GALACTOSE-6-SULFATE'>G6S</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n7a|2n7a]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7b OCA], [http://pdbe.org/2n7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7b RCSB], [http://www.ebi.ac.uk/pdbsum/2n7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SIGL8_HUMAN SIGL8_HUMAN]] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Allain, F H.T]] | |||
[[Category: Ernst, B]] | |||
[[Category: Proepster, J M]] | |||
[[Category: Rabbani, S]] | [[Category: Rabbani, S]] | ||
[[Category: Schubert, M]] | [[Category: Schubert, M]] | ||
[[Category: Yang, F]] | [[Category: Yang, F]] | ||
[[Category: Carbohydrate recognition]] | |||
[[Category: Carbohydrate-binding receptor]] | |||
[[Category: I-type lectin]] | |||
[[Category: Protein-glycan complex]] | |||
[[Category: Saf-2]] | |||
[[Category: Sialic acid-binding immunoglobulin-like lectin 8]] | |||
[[Category: Siglec8]] | |||
[[Category: Structural protein]] | |||
[[Category: Sulfated sialyl lewis x]] | |||
Revision as of 20:53, 13 July 2016
NMR structure of human I-type lectin domain-glycan complexNMR structure of human I-type lectin domain-glycan complex
Structural highlights
Function[SIGL8_HUMAN] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
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