4xv1: Difference between revisions

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==B-Raf Kinase V600E oncogenic mutant in complex with PLX7904==
==B-Raf Kinase V600E oncogenic mutant in complex with PLX7904==
<StructureSection load='4xv1' size='340' side='right' caption='[[4xv1]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
<StructureSection load='4xv1' size='340' side='right' caption='[[4xv1]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xv1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XV1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xv1]] is a 2 chain structure. The March 2016 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Raf Protein Kinases''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2016_3 10.2210/rcsb_pdb/mom_2016_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XV1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=904:N-(3-{[5-(2-CYCLOPROPYLPYRIMIDIN-5-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]CARBONYL}-2,4-DIFLUOROPHENYL)-N-ETHYL-N-METHYLSULFURIC+DIAMIDE'>904</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=904:N-(3-{[5-(2-CYCLOPROPYLPYRIMIDIN-5-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]CARBONYL}-2,4-DIFLUOROPHENYL)-N-ETHYL-N-METHYLSULFURIC+DIAMIDE'>904</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k0i|4k0i]], [[4k16|4k16]], [[4k1a|4k1a]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k0i|4k0i]], [[4k16|4k16]], [[4k1a|4k1a]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xv1 OCA], [http://pdbe.org/4xv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xv1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xv1 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xv1 OCA], [http://pdbe.org/4xv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xv1 RCSB], [http://www.ebi.ac.uk/pdbsum/4xv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xv1 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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</StructureSection>
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Raf Protein Kinases]]
[[Category: Zhang, C]]
[[Category: Zhang, C]]
[[Category: Zhang, Y]]
[[Category: Zhang, Y]]

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