4xv2: Difference between revisions
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==B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib== | ==B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib== | ||
<StructureSection load='4xv2' size='340' side='right' caption='[[4xv2]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4xv2' size='340' side='right' caption='[[4xv2]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xv2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XV2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4xv2]] is a 2 chain structure. The March 2016 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Raf Protein Kinases'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2016_3 10.2210/rcsb_pdb/mom_2016_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XV2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P06:DABRAFENIB'>P06</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P06:DABRAFENIB'>P06</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k04|4k04]], [[4k0i|4k0i]], [[4k16|4k16]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k04|4k04]], [[4k0i|4k0i]], [[4k16|4k16]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xv2 OCA], [http://pdbe.org/4xv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xv2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xv2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xv2 OCA], [http://pdbe.org/4xv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xv2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xv2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: RCSB PDB Molecule of the Month]] | |||
[[Category: Raf Protein Kinases]] | |||
[[Category: Zhang, Y]] | [[Category: Zhang, Y]] | ||
[[Category: Zhang, c]] | [[Category: Zhang, c]] | ||