CD3: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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 <StructureSection load='1sy6' size='450' side='right' caption='Structure of human CD3 extracellular domain (green) complex with antibody light chain (cyan) and heavy chain (red) (PDB entry [[1sy6]])' scene='55/551236/Cv/1'>
-'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM).  Drugs which bind to CD3 are tested as immunorepressants.<ref>PMID:24488493</ref>
+== Function ==
-*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).<ref>PMID:15136729</ref>
+'''CD3''' (or '''Cluster of Differentiation 3''') is a T-cell co-receptor.  The CD3 is composed of γ, δ and two ε chains.  These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes.  CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ.  The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM).  <ref>PMID:24488493</ref>
+*<scene name='55/551236/Cv/2'>Human CD3 extracellular domain with antibody light chain and heavy chain</scene> (PDB entry [[1sy6]]).
+== Relevance ==
+Drugs which bind to CD3 are tested as immunorepressants.
+<ref>PMID:15136729</ref>
 </StructureSection>