Cadherin: Difference between revisions

Revision as of 12:52, 16 November 2015

Function

Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons), P-CDH (placental). The CDH superfamily contains:
*Protocadhedrins (Prot-CDH) which are similar to CDH but are unique in their cytoplasmic domains. They are found mainly in the brain at cell-cell contacts.

Desmogleins (Des-CDH) are CDH found in desmosomes.

Structural highlights

The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed strand swap. The strand swapping is enhanced by 2 Trp residues docking into the hydrophobic pocket of the neighboring CDH molecule.

3D Structures of Cadherin3D Structures of Cadherin

Updated on 16-November-2015

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

@@ Line 1: / Line 1: @@
 <StructureSection load='2a4c' size='450' side='right' scene= caption='Lymnaea acetylcholine-binding protein pentamer complex with acetylcholine (PDB code 3wip)'>
 == Function ==
@@ Line 8: / Line 7: @@
 == Structural highlights ==
-The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''.
+The adhesive binding of CDH arises from the exchange of β strand of one CDH with the strand of CDH of a neighboring cell termed ''strand swap''.  The strand swapping is enhanced by 2 Trp residues docking into the hydrophobic pocket of the neighboring CDH molecule.
 </StructureSection>