Alpha-lytic protease: Difference between revisions

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<StructureSection load='1p05' size='350' side='right' caption='Structure of alpha-lytic protease complex with peptidyl-boronic acid inhibitor and sulfate (PDB entry [[1p05]])' scene=''>
<StructureSection load='3pro' size='350' side='right' caption='Structure of alpha-lytic protease complex with peptidyl-boronic acid inhibitor and sulfate (PDB entry [[3pro]])' scene=''>


'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family.  ALP is a two-domain enzyme.  One domain is a large pro region that catalyzes the folding of the protease.  The second domain is the protease domain.
'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family.  ALP is a two-domain enzyme.  One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease.  The second domain is the protease domain (residues 200-397).
</StructureSection>
</StructureSection>


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**[[2alp]], [[1p09]], [[1tal]], [[2ull]], [[1boq]], [[1ssz]], [[2h5c]], [[1ssx]] – LeALP – ''Lysobacter enzymogenes''  <BR />
**[[2alp]], [[1p09]], [[1tal]], [[2ull]], [[1boq]], [[1ssz]], [[2h5c]], [[1ssx]] – LeALP – ''Lysobacter enzymogenes''  <BR />
**[[1gba]], [[1gbe]], [[1gbj]], [[3urc]], [[3urd]], [[3ure]] – LeALP (mutant)  <BR />
**[[1gba]], [[1gbe]], [[1gbj]], [[3urc]], [[3urd]], [[3ure]], [[1qq4]] – LeALP (mutant)  <BR />
**[[1p01]], [[1p02]], [[1p03]], [[1p04]], [[1p05]], [[1p06]], [[1p10]], [[2lpr]], [[3lpr]], [[5lpr]], [[6lpr]], [[7lpr]], [[8lpr]], [[9lpr]], [[2h5d]] – LeALP + boronic acid inhibitor  <BR />
**[[1p01]], [[1p02]], [[1p03]], [[1p04]], [[1p05]], [[1p06]], [[1p10]], [[2lpr]], [[3lpr]], [[5lpr]], [[6lpr]], [[7lpr]], [[8lpr]], [[9lpr]], [[2h5d]] – LeALP + boronic acid inhibitor  <BR />
**[[1gbb]], [[1gbc]], [[1gbd]], [[1gbf]], [[1gbh]], [[1gbi]], [[1gbk]], [[1gbl]], [[1gbm]] – LeALP (mutant) + boronic acid inhibitor  <BR />
**[[1gbb]], [[1gbc]], [[1gbd]], [[1gbf]], [[1gbh]], [[1gbi]], [[1gbk]], [[1gbl]], [[1gbm]] – LeALP (mutant) + boronic acid inhibitor  <BR />
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**[[3qgj]] – LeALP + peptide  <BR />
**[[3qgj]] – LeALP + peptide  <BR />


*ALP including pro region
*ALP pro region


**[[2pro]], [[1qrx]] – LeALP pro region  <BR />
**[[2pro]], [[1qrx]] – LeALP pro region  <BR />
**[[1qq4]], [[1qrw]], [[3m7t]], [[3m7u]] – LeALP pro region (mutant) <BR />
**[[1qrw]], [[3m7t]], [[3m7u]] – LeALP pro region (mutant) <BR />
**[[3pro]] – LeALP (mutant) + pro region  <BR />
 
**[[4pro]] – LeALP (mutant) + pro region (mutant) <BR />
*ALP pro+protease domains
 
**[[3pro]], [[4pro]] – LeALP (mutant) <BR />
 
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 12:38, 29 October 2015


Alpha-lytic protease (ALP) is a bacterial serine protease of the chymotrypsin family. ALP is a two-domain enzyme. One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease. The second domain is the protease domain (residues 200-397).

Structure of alpha-lytic protease complex with peptidyl-boronic acid inhibitor and sulfate (PDB entry 3pro)

Drag the structure with the mouse to rotate

3D Structures of alpha-lytic protease3D Structures of alpha-lytic protease

Updated on 29-October-2015

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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