ABC transporter: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
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ABC Transporters have two main functionalities acting either as exporters or importers. '''ABC ''Exporters''''' release bound drugs to the extracellular environment, while '''ABC ''Importers''''' accept substrate molecules from their relevant substrate-binding proteins<ref name="biochembook"/>. For instance the Vitamin B12 transporter BtuCD (PDB [[1l7v]]) is a binding protein-dependent ABC transporter system that uses the power of ATP hydrolysis to pump vitamin B12 into the cytoplasm of E. coli<ref name="BtuCD-Ecoli"/>. | ABC Transporters have two main functionalities acting either as exporters or importers. '''ABC ''Exporters''''' release bound drugs to the extracellular environment, while '''ABC ''Importers''''' accept substrate molecules from their relevant substrate-binding proteins<ref name="biochembook"/>. For instance the Vitamin B12 transporter BtuCD (PDB [[1l7v]]) is a binding protein-dependent ABC transporter system that uses the power of ATP hydrolysis to pump vitamin B12 into the cytoplasm of E. coli<ref name="BtuCD-Ecoli"/>. | ||
== Structural highlights == | == Structural highlights == | ||
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== Disease == | == Disease == | ||
There are currently 50 known ABC transporters in human. Of these there are 13 genetic diseases known to be associated with 14 of them. Among the diseases are cystic fibrosis, Stargardt disease, age-related macular degeneration and others. | There are currently 50 known ABC transporters in human. Of these there are 13 genetic diseases known to be associated with 14 of them. Among the diseases are cystic fibrosis, Stargardt disease, age-related macular degeneration and others. '''ABC Exporters''' use ATP to drive import and export functions providing multidrug resistance. In eukaryoles, for instance, ABC Transporters are problematic because they export therapeutic drugs such as those used in chemotherapy regimens, which must be changed frequently to avoid the rejection of the drugs<ref name="biochembook"/>. | ||
</StructureSection> | </StructureSection> | ||