2p4u: Difference between revisions
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{{Structure | {{Structure | ||
|PDB= 2p4u |SIZE=350|CAPTION= <scene name='initialview01'>2p4u</scene>, resolution 1.900Å | |PDB= 2p4u |SIZE=350|CAPTION= <scene name='initialview01'>2p4u</scene>, resolution 1.900Å | ||
|SITE= | |SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+201'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+B+201'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+C+201'>AC3</scene> and <scene name='pdbsite=AC4:Po4+Binding+Site+For+Residue+D+201'>AC4</scene> | ||
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | ||
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span> | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span> | ||
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'''Crystal structure of acid phosphatase 1 (Acp1) from Mus musculus''' | '''Crystal structure of acid phosphatase 1 (Acp1) from Mus musculus''' | ||
==Overview== | |||
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases. | |||
==About this Structure== | ==About this Structure== | ||
2P4U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4U OCA]. | 2P4U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4U OCA]. | ||
==Reference== | |||
Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037] | |||
[[Category: Acid phosphatase]] | [[Category: Acid phosphatase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| Line 25: | Line 31: | ||
[[Category: Freeman, J.]] | [[Category: Freeman, J.]] | ||
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]] | [[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]] | ||
[[Category: Sauder, M | [[Category: Sauder, J M.]] | ||
[[Category: Smith, D.]] | [[Category: Smith, D.]] | ||
[[Category: Wasserman, S.]] | [[Category: Wasserman, S.]] | ||
| Line 37: | Line 43: | ||
[[Category: structural genomic]] | [[Category: structural genomic]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 10:02:14 2008'' | ||
Revision as of 11:02, 26 March 2008
| |||||||
| , resolution 1.900Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , and | ||||||
| Ligands: | |||||||
| Gene: | Acp1 (Mus musculus) | ||||||
| Activity: | Acid phosphatase, with EC number 3.1.3.2 | ||||||
| Domains: | LMWPc, LMWPc | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of acid phosphatase 1 (Acp1) from Mus musculus
OverviewOverview
The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
About this StructureAbout this Structure
2P4U is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Acid phosphatase
- Mus musculus
- Single protein
- Almo, S C.
- Bain, K T.
- Bonanno, J B.
- Burley, S K.
- Freeman, J.
- NYSGXRC, New York Structural GenomiX Research Consortium.
- Sauder, J M.
- Smith, D.
- Wasserman, S.
- Wu, B.
- Xu, W.
- Hydrolase
- New york structural genomix research consortium
- Nysgxrc
- Protein structure initiative
- Psi-2
- Structural genomic