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==CATALYTIC ANTIBODY D2.3 COMPLEX== | ==CATALYTIC ANTIBODY D2.3 COMPLEX== | ||
<StructureSection load='1kn2' size='340' side='right' caption='[[1kn2]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1kn2' size='340' side='right' caption='[[1kn2]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kn2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1kn2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KN2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNE:PARA-NITROPHENYL+PHOSPHONOBUTANOYL+L-ALANINE'>PNE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNE:PARA-NITROPHENYL+PHOSPHONOBUTANOYL+L-ALANINE'>PNE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yec|1yec]], [[1yef|1yef]], [[1yeg|1yeg]], [[1yeh|1yeh]], [[1yei|1yei]], [[1yej|1yej]], [[1yek|1yek]], [[1kn4|1kn4]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yec|1yec]], [[1yef|1yef]], [[1yeg|1yeg]], [[1yeh|1yeh]], [[1yei|1yei]], [[1yej|1yej]], [[1yek|1yek]], [[1kn4|1kn4]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kn2 OCA], [http://pdbe.org/1kn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kn2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kn2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kn2 OCA], [http://pdbe.org/1kn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kn2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kn2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kn2 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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==See Also== | ==See Also== | ||
*[[ | *[[3D structures of monoclonal antibody|3D structures of monoclonal antibody]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Gigant, B]] | [[Category: Gigant, B]] | ||
[[Category: Knossow, M]] | [[Category: Knossow, M]] | ||
Revision as of 10:25, 11 October 2017
CATALYTIC ANTIBODY D2.3 COMPLEXCATALYTIC ANTIBODY D2.3 COMPLEX
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe crystal structures of catalytic antibody D2.3 Fab with the two enantiomers, 7D and 7L, which represent transition state analogues for the hydrolysis of the corresponding esters, 6D and 6L, were determined to better understand remarkable reactivity differences: the L-ester displayed significantly tighter binding (K(M)) and increased catalytic activity (k(cat)) with D2.3, even though the chiral center is 7 bonds distant from the reaction center. Surprisingly, the electron densities of the liganded phosphonates, 7D and 7L, within the D2.3 binding/reaction site were essentially identical, highlighting the subtle influences of protein interactions on chemical behavior. Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody.,D'Souza LJ, Gigant B, Knossow M, Green BS J Am Chem Soc. 2002 Mar 13;124(10):2114-5. PMID:11878955[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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