1v0z: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
== | |||
==Structure of Neuraminidase from English duck subtype N6== | |||
<StructureSection load='1v0z' size='340' side='right' caption='[[1v0z]], [[Resolution|resolution]] 1.84Å' scene=''> | <StructureSection load='1v0z' size='340' side='right' caption='[[1v0z]], [[Resolution|resolution]] 1.84Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| Line 6: | Line 7: | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a14|1a14]], [[1a4g|1a4g]], [[1a4q|1a4q]], [[1b9s|1b9s]], [[1b9t|1b9t]], [[1b9v|1b9v]], [[1bji|1bji]], [[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1euu|1euu]], [[1f8b|1f8b]], [[1f8c|1f8c]], [[1f8d|1f8d]], [[1f8e|1f8e]], [[1inf|1inf]], [[1ing|1ing]], [[1inh|1inh]], [[1inv|1inv]], [[1inw|1inw]], [[1inx|1inx]], [[1iny|1iny]], [[1ivb|1ivb]], [[1ivc|1ivc]], [[1ivd|1ivd]], [[1ive|1ive]], [[1ivf|1ivf]], [[1ivg|1ivg]], [[1kit|1kit]], [[1l7f|1l7f]], [[1l7g|1l7g]], [[1l7h|1l7h]], [[1mwe|1mwe]], [[1nca|1nca]], [[1ncb|1ncb]], [[1ncc|1ncc]], [[1ncd|1ncd]], [[1nma|1nma]], [[1nmb|1nmb]], [[1nmc|1nmc]], [[1nn2|1nn2]], [[1nna|1nna]], [[1nnb|1nnb]], [[1nnc|1nnc]], [[1nsb|1nsb]], [[1nsc|1nsc]], [[1nsd|1nsd]], [[1usr|1usr]], [[1usx|1usx]], [[1v2i|1v2i]], [[1v3b|1v3b]], [[1v3c|1v3c]], [[1v3d|1v3d]], [[1v3e|1v3e]], [[1vcj|1vcj]], [[1w1x|1w1x]], [[1w20|1w20]], [[1w21|1w21]], [[1w8n|1w8n]], [[1w8o|1w8o]], [[1xoe|1xoe]], [[1xog|1xog]], [[1z4v|1z4v]], [[1z4w|1z4w]], [[1z4x|1z4x]], [[1z4y|1z4y]], [[1z4z|1z4z]], [[1z50|1z50]], [[2bat|2bat]], [[2qwa|2qwa]], [[2qwb|2qwb]], [[2qwc|2qwc]], [[2qwd|2qwd]], [[2qwe|2qwe]], [[2qwf|2qwf]], [[2qwg|2qwg]], [[2qwh|2qwh]], [[2qwi|2qwi]], [[2qwj|2qwj]], [[2qwk|2qwk]], [[2sil|2sil]], [[2sim|2sim]], [[3nn9|3nn9]], [[4nn9|4nn9]], [[5nn9|5nn9]], [[6nn9|6nn9]], [[7nn9|7nn9]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a14|1a14]], [[1a4g|1a4g]], [[1a4q|1a4q]], [[1b9s|1b9s]], [[1b9t|1b9t]], [[1b9v|1b9v]], [[1bji|1bji]], [[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1euu|1euu]], [[1f8b|1f8b]], [[1f8c|1f8c]], [[1f8d|1f8d]], [[1f8e|1f8e]], [[1inf|1inf]], [[1ing|1ing]], [[1inh|1inh]], [[1inv|1inv]], [[1inw|1inw]], [[1inx|1inx]], [[1iny|1iny]], [[1ivb|1ivb]], [[1ivc|1ivc]], [[1ivd|1ivd]], [[1ive|1ive]], [[1ivf|1ivf]], [[1ivg|1ivg]], [[1kit|1kit]], [[1l7f|1l7f]], [[1l7g|1l7g]], [[1l7h|1l7h]], [[1mwe|1mwe]], [[1nca|1nca]], [[1ncb|1ncb]], [[1ncc|1ncc]], [[1ncd|1ncd]], [[1nma|1nma]], [[1nmb|1nmb]], [[1nmc|1nmc]], [[1nn2|1nn2]], [[1nna|1nna]], [[1nnb|1nnb]], [[1nnc|1nnc]], [[1nsb|1nsb]], [[1nsc|1nsc]], [[1nsd|1nsd]], [[1usr|1usr]], [[1usx|1usx]], [[1v2i|1v2i]], [[1v3b|1v3b]], [[1v3c|1v3c]], [[1v3d|1v3d]], [[1v3e|1v3e]], [[1vcj|1vcj]], [[1w1x|1w1x]], [[1w20|1w20]], [[1w21|1w21]], [[1w8n|1w8n]], [[1w8o|1w8o]], [[1xoe|1xoe]], [[1xog|1xog]], [[1z4v|1z4v]], [[1z4w|1z4w]], [[1z4x|1z4x]], [[1z4y|1z4y]], [[1z4z|1z4z]], [[1z50|1z50]], [[2bat|2bat]], [[2qwa|2qwa]], [[2qwb|2qwb]], [[2qwc|2qwc]], [[2qwd|2qwd]], [[2qwe|2qwe]], [[2qwf|2qwf]], [[2qwg|2qwg]], [[2qwh|2qwh]], [[2qwi|2qwi]], [[2qwj|2qwj]], [[2qwk|2qwk]], [[2sil|2sil]], [[2sim|2sim]], [[3nn9|3nn9]], [[4nn9|4nn9]], [[5nn9|5nn9]], [[6nn9|6nn9]], [[7nn9|7nn9]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0z OCA], [http://pdbe.org/1v0z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v0z RCSB], [http://www.ebi.ac.uk/pdbsum/1v0z PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v0z OCA], [http://pdbe.org/1v0z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1v0z RCSB], [http://www.ebi.ac.uk/pdbsum/1v0z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1v0z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| Line 14: | Line 15: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0z_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/1v0z_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v0z ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
Revision as of 10:57, 28 March 2018
Structure of Neuraminidase from English duck subtype N6Structure of Neuraminidase from English duck subtype N6
Structural highlights
Function[NRAM_I56A2] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
| ||||||||||||||||||||