2o8d: Difference between revisions

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|PDB= 2o8d |SIZE=350|CAPTION= <scene name='initialview01'>2o8d</scene>, resolution 3.000&Aring;
|PDB= 2o8d |SIZE=350|CAPTION= <scene name='initialview01'>2o8d</scene>, resolution 3.000&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=DU:2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>DU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
|ACTIVITY=  
|ACTIVITY=  
|GENE= MSH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), MSH6, GTBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= MSH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), MSH6, GTBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[2o8b|2O8B]], [[2o8c|2O8C]], [[2o8e|2O8E]], [[2o8f|2O8F]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o8d OCA], [http://www.ebi.ac.uk/pdbsum/2o8d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o8d RCSB]</span>
}}
}}


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==Disease==
==Disease==
Known diseases associated with this structure: Colorectal cancer, hereditary nonpolyposis, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Colorectal cancer, hereditary nonpolyposis, type 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600678 600678]], Endometrial cancer, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600678 600678]], Mismatch repair cancer syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600678 600678]], Mismatch repair cancer syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Muir-Torre syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Ovarian cancer, endometrial type. 608089 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600678 600678]]
Known disease associated with this structure: Colorectal cancer, hereditary nonpolyposis, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Mismatch repair cancer syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]], Muir-Torre syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609309 609309]]


==About this Structure==
==About this Structure==
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[[Category: Pohlhaus, T J.]]
[[Category: Pohlhaus, T J.]]
[[Category: Warren, J J.]]
[[Category: Warren, J J.]]
[[Category: ADP]]
[[Category: MG]]
[[Category: cancer]]
[[Category: cancer]]
[[Category: dna damage response]]
[[Category: dna damage response]]
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[[Category: somatic hypermutation]]
[[Category: somatic hypermutation]]


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