1b36: Difference between revisions
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==SOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURES== | ==SOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURES== | ||
<StructureSection load='1b36' size='340' side='right' caption='[[1b36]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | <StructureSection load='1b36' size='340' side='right' caption='[[1b36]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1b36]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B36 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1b36]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B36 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b36 OCA], [http://pdbe.org/1b36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b36 RCSB], [http://www.ebi.ac.uk/pdbsum/1b36 PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b36 OCA], [http://pdbe.org/1b36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b36 RCSB], [http://www.ebi.ac.uk/pdbsum/1b36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b36 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
Revision as of 09:15, 17 August 2017
SOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURESSOLUTION STRUCTURE OF THE HAIRPIN RIBOZYME LOOP B DOMAIN RNA, NMR, 10 STRUCTURES
Structural highlights
Publication Abstract from PubMedThe hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain. Solution structure of the loop B domain from the hairpin ribozyme.,Butcher SE, Allain FH, Feigon J Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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