1st0: Difference between revisions
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|PDB= 1st0 |SIZE=350|CAPTION= <scene name='initialview01'>1st0</scene>, resolution 1.9Å | |PDB= 1st0 |SIZE=350|CAPTION= <scene name='initialview01'>1st0</scene>, resolution 1.9Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE'>GTG</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= DCPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= DCPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1st4|1ST4]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1st0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1st0 OCA], [http://www.ebi.ac.uk/pdbsum/1st0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1st0 RCSB]</span> | |||
}} | }} | ||
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[[Category: Liu, H.]] | [[Category: Liu, H.]] | ||
[[Category: Liu, S W.]] | [[Category: Liu, S W.]] | ||
[[Category: cap]] | [[Category: cap]] | ||
[[Category: decapping]] | [[Category: decapping]] | ||
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[[Category: rna decay]] | [[Category: rna decay]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:46:35 2008'' | ||
Revision as of 23:46, 30 March 2008
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| , resolution 1.9Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | DCPS (Homo sapiens) | ||||||
| Related: | 1ST4
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of DcpS bound to m7GpppG
OverviewOverview
Complete removal of residual N-7 guanine cap from degraded messenger RNA is necessary to prevent accumulation of intermediates that might interfere with RNA processing, export, and translation. The human scavenger decapping enzyme, DcpS, catalyzes residual cap hydrolysis following mRNA degradation, releasing N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. DcpS structures bound to m(7)GpppG or m(7)GpppA reveal an asymmetric DcpS dimer that simultaneously creates an open nonproductive DcpS-cap complex and a closed productive DcpS-cap complex that alternate via 30 A domain movements. Structural and biochemical analysis suggests an autoregulatory mechanism whereby premature decapping mRNA is prevented by blocking the conformational changes that are required to form a closed productive active site capable of cap hydrolysis.
About this StructureAbout this Structure
1ST0 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1ST0 with [Exosomes]. Full crystallographic information is available from OCA.
ReferenceReference
Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity., Gu M, Fabrega C, Liu SW, Liu H, Kiledjian M, Lima CD, Mol Cell. 2004 Apr 9;14(1):67-80. PMID:15068804
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