1m7b: Difference between revisions
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|PDB= 1m7b |SIZE=350|CAPTION= <scene name='initialview01'>1m7b</scene>, resolution 2.00Å | |PDB= 1m7b |SIZE=350|CAPTION= <scene name='initialview01'>1m7b</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Rnd3 (amino acids 19-200) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= Rnd3 (amino acids 19-200) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m7b OCA], [http://www.ebi.ac.uk/pdbsum/1m7b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m7b RCSB]</span> | |||
}} | }} | ||
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[[Category: Stege, P.]] | [[Category: Stege, P.]] | ||
[[Category: Vetter, I R.]] | [[Category: Vetter, I R.]] | ||
[[Category: small gtpase]] | [[Category: small gtpase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:12:20 2008'' | ||
Revision as of 22:12, 30 March 2008
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| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | Rnd3 (amino acids 19-200) (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Rnd3/RhoE: functional implications
OverviewOverview
The Rnd proteins constitute an exceptional subfamily within the Rho GTPase family. They possess extended chains at both termini and four prominent amino acid deviations causing GTPase deficiency. Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A resolution. This is the first GTP-structure of a Rho family member which reveals a similar fold but striking differences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii) C3-transferase binding site and (iv) interacting interfaces towards RhoA regulators and effectors.
About this StructureAbout this Structure
1M7B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of Rnd3/RhoE: functional implications., Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR, FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:12163169
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