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==MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA== | ==MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA== | ||
<StructureSection load='173d' size='340' side='right' caption='[[173d]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='173d' size='340' side='right' caption='[[173d]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[173d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=173D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=173D FirstGlance]. <br> | <table><tr><td colspan='2'>[[173d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. The April 2013 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Actinomy'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2013_4 10.2210/rcsb_pdb/mom_2013_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=173D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=173D FirstGlance]. <br> | ||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=PXZ:2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE'>PXZ</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=PXZ:2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE'>PXZ</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a7z|1a7z]], [[209d|209d]], [[1unm|1unm]], [[1i3w|1i3w]], [[1a7y|1a7y]], [[1fja|1fja]], [[2d55|2d55]], [[1dsc|1dsc]], [[1l1v|1l1v]], [[316d|316d]], [[1dsd|1dsd]], [[1mnv|1mnv]], [[1unj|1unj]], [[1ovf|1ovf]], [[1qfi|1qfi]], [[172d|172d]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a7z|1a7z]], [[209d|209d]], [[1unm|1unm]], [[1i3w|1i3w]], [[1a7y|1a7y]], [[1fja|1fja]], [[2d55|2d55]], [[1dsc|1dsc]], [[1l1v|1l1v]], [[316d|316d]], [[1dsd|1dsd]], [[1mnv|1mnv]], [[1unj|1unj]], [[1ovf|1ovf]], [[1qfi|1qfi]], [[172d|172d]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=173d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=173d OCA], [http://pdbe.org/173d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=173d RCSB], [http://www.ebi.ac.uk/pdbsum/173d PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=173d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=173d OCA], [http://pdbe.org/173d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=173d RCSB], [http://www.ebi.ac.uk/pdbsum/173d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=173d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Actinomy]] | |||
[[Category: RCSB PDB Molecule of the Month]] | |||
[[Category: Streptomyces antibioticus]] | [[Category: Streptomyces antibioticus]] | ||
[[Category: Kamitori, S]] | [[Category: Kamitori, S]] | ||
Revision as of 12:20, 9 August 2017
MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNAMULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA
Structural highlights
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