PLC beta 3 Gq: Difference between revisions
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'''Overview of the PLC-β3 and Gαq interface:''' | '''Overview of the PLC-β3 and Gαq interface:''' | ||
The Gαq subunit consists two domains, one is <scene name='70/701452/ | The Gαq subunit consists two domains, one is <scene name='70/701452/Gtpase_domain/2'>the GTPase domain</scene> and the other is the alpha helical domain. These domains include three regions called <scene name='70/701452/Fig2/7'>switch regions I-III</scene>.These regions allows the Gαq to be released from the receptor and activate distinct downstream effectors, which carry on the signal to downstream targets. A central effector of Gαq being the PLC-β3 enzyme. The switch regions I and II interact with several domains in PLC-β3. | ||
<scene name='70/701452/Fig1/9'>The PLC-β3 has several domains</scene> consisting of N-terminal PH domain, a series of four EF hands, a catalytic TIM barrel that the X/Y linker connect its two halves and a C2 domain. | <scene name='70/701452/Fig1/9'>The PLC-β3 has several domains</scene> consisting of N-terminal PH domain, a series of four EF hands, a catalytic TIM barrel that the X/Y linker connect its two halves and a C2 domain. |