PLC beta 3 Gq: Difference between revisions

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'''Overview of the PLC-β3 and Gαq interface:'''  
'''Overview of the PLC-β3 and Gαq interface:'''  


The Gαq subunit consists two domains, one is <scene name='70/701452/the Gtpase_domain/2'>GTPase domain</scene> and the other is the alpha helical domain. These domains include three regions called <scene name='70/701452/Fig2/7'>switch regions I-III</scene>.These regions allows the Gαq to be released from the receptor and activate distinct downstream effectors, which carry on the signal to downstream targets. A central effector of Gαq being the PLC-β3 enzyme. The switch regions I and II  interact with several domains in PLC-β3.
The Gαq subunit consists two domains, one is <scene name='70/701452/Gtpase_domain/2'>the GTPase domain</scene> and the other is the alpha helical domain. These domains include three regions called <scene name='70/701452/Fig2/7'>switch regions I-III</scene>.These regions allows the Gαq to be released from the receptor and activate distinct downstream effectors, which carry on the signal to downstream targets. A central effector of Gαq being the PLC-β3 enzyme. The switch regions I and II  interact with several domains in PLC-β3.


<scene name='70/701452/Fig1/9'>The PLC-β3 has several domains</scene> consisting of N-terminal PH domain, a series of four EF hands, a catalytic TIM barrel that the X/Y linker connect its two halves and a C2 domain.
<scene name='70/701452/Fig1/9'>The PLC-β3 has several domains</scene> consisting of N-terminal PH domain, a series of four EF hands, a catalytic TIM barrel that the X/Y linker connect its two halves and a C2 domain.

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