6fit: Difference between revisions
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|PDB= 6fit |SIZE=350|CAPTION= <scene name='initialview01'>6fit</scene>, resolution 2.6Å | |PDB= 6fit |SIZE=350|CAPTION= <scene name='initialview01'>6fit</scene>, resolution 2.6Å | ||
|SITE= <scene name='pdbsite=AVE:Active+Site+HIS+Responsible+For+Forming+The+Transient+Nu+...'>AVE</scene> and <scene name='pdbsite=HNE:HIS+Triad+For+Which+This+Family+Was+Named'>HNE</scene> | |SITE= <scene name='pdbsite=AVE:Active+Site+HIS+Responsible+For+Forming+The+Transient+Nu+...'>AVE</scene> and <scene name='pdbsite=HNE:HIS+Triad+For+Which+This+Family+Was+Named'>HNE</scene> | ||
|LIGAND= <scene name='pdbligand=AMW:ADENOSINE MONOTUNGSTATE'>AMW</scene> | |LIGAND= <scene name='pdbligand=AMW:ADENOSINE+MONOTUNGSTATE'>AMW</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Bis(5'-adenosyl)-triphosphatase Bis(5'-adenosyl)-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.29 3.6.1.29] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-adenosyl)-triphosphatase Bis(5'-adenosyl)-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.29 3.6.1.29] </span> | ||
|GENE= FHIT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= FHIT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fit OCA], [http://www.ebi.ac.uk/pdbsum/6fit PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=6fit RCSB]</span> | |||
}} | }} | ||
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[[Category: Klein, M G.]] | [[Category: Klein, M G.]] | ||
[[Category: Lima, C D.]] | [[Category: Lima, C D.]] | ||
[[Category: fhit]] | [[Category: fhit]] | ||
[[Category: fragile histidine triad protein]] | [[Category: fragile histidine triad protein]] | ||
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[[Category: putative tumor suppressor]] | [[Category: putative tumor suppressor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:42:55 2008'' | ||
Revision as of 05:42, 31 March 2008
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| , resolution 2.6Å | |||||||
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| Sites: | and | ||||||
| Ligands: | |||||||
| Gene: | FHIT (Homo sapiens) | ||||||
| Activity: | Bis(5'-adenosyl)-triphosphatase, with EC number 3.6.1.29 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
FHIT-TRANSITION STATE ANALOG
OverviewOverview
The histidine triad (HIT) protein family is among the most ubiquitous and highly conserved in nature, but a biological activity has not yet been identified for any member of the HIT family. Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions. Crystallographic structures of apo, substrate analog, pentacovalent transition-state analog, and product states of both enzymes reveal a catalytic mechanism and define substrate characteristics required for catalysis, thus unifying the HIT family as nucleotidyl hydrolases, transferases, or both. The approach described here may be useful in identifying structure-function relations between protein families identified through genomics.
About this StructureAbout this Structure
6FIT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:9323207
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