Receptor for activated protein kinase C 1: Difference between revisions
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<StructureSection load='4aow' size='340' side='right' caption='Human receptor for activated protein kinase C 1 complex with glycerol (PDB code [[4aow]])' scene=''> | <StructureSection load='4aow' size='340' side='right' caption='Human receptor for activated protein kinase C 1 complex with glycerol (PDB code [[4aow]])' scene=''> | ||
== Function == | == Function == | ||
'''Receptor for activated protein kinase C 1''' (RACK1) is a scaffold protein which is able to interact simultaneously with several signaling molecules<ref>PMID:17908799</ref>. It binds to protein kinases and to membrane-bound receptors<ref>PMID:9584165</ref>. RACK1 is also part of the eukaryotic ribosome and it localizes to the small 40S subunit. RACK1 recruits activated protein kinase to the ribosome and allows translation to be linked to cellular stimuli<ref>PMID:15577927</ref>. | |||
== Disease == | == Disease == | ||
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[[1trj]] – yRACK1 + RNA – Cryo EM <br /> | [[1trj]] – yRACK1 + RNA – Cryo EM <br /> | ||
[[3j6x]], [[3j6y]], [[4v6i]], [[4v7r]], [[3j77]], [[3j78]], [[4u3m]], [[4u3n]], [[4u3u]], [[4u4n]], [[4u4o]], [[4u4r]], [[4u4u]], [[4u4y]], [[4u4z]], [[4u50]], [[4u51]], [[4u52]], [[4u53]], [[4u55]], [[4u56]], [[4u6f]] – yRACK1 in y80S ribosome – Cryo EM <br /> | [[3j6x]], [[3j6y]], [[4v6i]], [[4v7r]], [[3j77]], [[3j78]], [[4u3m]], [[4u3n]], [[4u3u]], [[4u4n]], [[4u4o]], [[4u4r]], [[4u4u]], [[4u4y]], [[4u4z]], [[4u50]], [[4u51]], [[4u52]], [[4u53]], [[4u55]], [[4u56]], [[4u6f]] – yRACK1 in y80S ribosome – Cryo EM <br /> | ||
[[4v6x]], [[5aj0]], [[4ug0]], [[5a2q]] – hRACK1 in h80S ribosome – Cryo EM <br | [[4v6x]], [[5aj0]], [[4ug0]], [[5a2q]] – hRACK1 in h80S ribosome – Cryo EM <br/> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 11:27, 3 August 2016
FunctionReceptor for activated protein kinase C 1 (RACK1) is a scaffold protein which is able to interact simultaneously with several signaling molecules[1]. It binds to protein kinases and to membrane-bound receptors[2]. RACK1 is also part of the eukaryotic ribosome and it localizes to the small 40S subunit. RACK1 recruits activated protein kinase to the ribosome and allows translation to be linked to cellular stimuli[3]. DiseaseRelevanceStructural highlights |
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3D Structures of receptor for activated protein kinase C 13D Structures of receptor for activated protein kinase C 1
Updated on 03-August-2016
3frx, 3rfg, 3rfh – yRACK1 – yeast
4aow – hRACK1 – human
1trj – yRACK1 + RNA – Cryo EM
3j6x, 3j6y, 4v6i, 4v7r, 3j77, 3j78, 4u3m, 4u3n, 4u3u, 4u4n, 4u4o, 4u4r, 4u4u, 4u4y, 4u4z, 4u50, 4u51, 4u52, 4u53, 4u55, 4u56, 4u6f – yRACK1 in y80S ribosome – Cryo EM
4v6x, 5aj0, 4ug0, 5a2q – hRACK1 in h80S ribosome – Cryo EM
ReferencesReferences
- ↑ Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ. RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol. 2007 Dec;27(23):8296-305. Epub 2007 Oct 1. PMID:17908799 doi:http://dx.doi.org/10.1128/MCB.00598-07
- ↑ Chang BY, Conroy KB, Machleder EM, Cartwright CA. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells. Mol Cell Biol. 1998 Jun;18(6):3245-56. PMID:9584165
- ↑ Nilsson J, Sengupta J, Frank J, Nissen P. Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep. 2004 Dec;5(12):1137-41. PMID:15577927 doi:http://dx.doi.org/10.1038/sj.embor.7400291