Stathmin: Difference between revisions
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<StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code [[3ryf]])' scene=''> | <StructureSection load='3ryf' size='340' side='right' caption='Rat stathmin SLD domain (magenta) complex with tubulin α chain (grey, pink), tubulin β chain (green, yellow), GTP, sulfate and Mg+2 ions (PDB code [[3ryf]])' scene=''> | ||
== Function == | == Function == | ||
'''Stathmin''' (STM) regulates microtubules dynamics. Microtubules undergo continuous assembly and disassembly in the cell’s cytoskeleton. STM binds to tubulin and prevents the latter from polymerization thus preventing microtubule assembly. Phosphorylation of STM weakens the binding of STM to tubulin enabling the microtubule assembly needed for the formation of mitotic spindle. Thus, STM is an oncoprotein. STM contains an SLD (Stathmin-Like Domain) domain of 149 residues which binds the tubulin dimer<ref>PMID:15216892</ref>. | |||
== Disease == | == Disease == | ||
Decreased levels of STM are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>. | |||
== Relevance == | == Relevance == | ||
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**[[1sa1]], [[1z2b]] – rSTM + tubulin + GTP + GDP + anti-wart drug <br /> | **[[1sa1]], [[1z2b]] – rSTM + tubulin + GTP + GDP + anti-wart drug <br /> | ||
**[[4eb6]] – rSTM (mutant) + tubulin + GTP + GDP + anti-cancer drug <br /> | **[[4eb6]] – rSTM (mutant) + tubulin + GTP + GDP + anti-cancer drug <br /> | ||
**[[3du7]] – rSTM + tubulin + GTP + GDP + phomopsine + | **[[3du7]] – rSTM + tubulin + GTP + GDP + phomopsine + anti-gout drug <br /> | ||
**[[3e22]] – rSTM + tubulin + GTP + GDP + soblidotine + | **[[3e22]] – rSTM + tubulin + GTP + GDP + soblidotine + anti-gout drug <br /> | ||
**[[3ut5]] – rSTM (mutant) + tubulin + GTP + GDP + ustiloxine + | **[[3ut5]] – rSTM (mutant) + tubulin + GTP + GDP + ustiloxine + anti-gout drug + Vinca tetrapeptide<br /> | ||
*Stathmin SLD domain complex with tubulin and tubulin tyrosine ligase | *Stathmin SLD domain complex with tubulin and tubulin tyrosine ligase | ||