Rho guanine nucleotide exchange factor: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain complex with transforming protein RhoA (PDB code 3kz1)' sc... |
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<StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey and green) complex with transforming protein RhoA (magenta and cyan), GSP and Mg+2 ion (PDB code [[3kz1]])' scene=''> | |||
<StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain complex with transforming protein RhoA (PDB code [[3kz1]])' scene=''> | |||
'''Rho guanine nucleotide exchange factor''' (Rho) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of Rho to GDP-GTPase catalyzes the dissociation of GDP from the protein. Rho domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences. | '''Rho guanine nucleotide exchange factor''' (Rho) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of Rho to GDP-GTPase catalyzes the dissociation of GDP from the protein. Rho domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences. | ||