4d7f: Difference between revisions

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-'''Unreleased structure'''
+==Human FXIa in complex with small molecule inhibitors.==
+<StructureSection load='4d7f' size='340' side='right' caption='[[4d7f]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
-The entry 4d7f is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4d7f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D7F FirstGlance]. <br>
-Authors: Sandmark, J., Oster, L., Jacso, T., Ullah, V., Redzick, A., Borjesson, U., Olsson, T., Norberg, M., Akerud, T.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IXA:N-[(2S)-1-({4-[(DIAMINOMETHYLIDENE)AMINO]BUTYL}AMINO)-1-OXO-3-PHENYLPROPAN-2-YL]-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-6-CARBOXAMIDE'>IXA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d76|4d76]], [[4d7g|4d7g]]</td></tr>
-Description: Human FXIa in complex with small molecule inhibitors.
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7f OCA], [http://pdbe.org/4d7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d7f RCSB], [http://www.ebi.ac.uk/pdbsum/4d7f PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[http://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Coagulation factor XIa]]
+[[Category: Akerud, T]]
+[[Category: Borjesson, U]]
+[[Category: Jacso, T]]
 [[Category: Norberg, M]]
+[[Category: Olsson, T]]
+[[Category: Oster, L]]
 [[Category: Redzick, A]]
-[[Category: Oster, L]]
+[[Category: Sandmark, J]]
 [[Category: Ullah, V]]
-[[Category: Olsson, T]]
+[[Category: Hydrolase]]
-[[Category: Akerud, T]]
+[[Category: Serine protease]]
-[[Category: Borjesson, U]]
-[[Category: Sandmark, J]]
-[[Category: Jacso, T]]