Ribosome recycling factor

Ribosome recycling factor (RRF) acts in releasing the ribosome from mRNA after completion of protein synthesis. RRF splits the ribosome into its small and large subunits. RRF is used together with elongation factor G in achieving this separation. RRF is a structural mimic of tRNA but binds to the ribosome differently than the A-site, P-site or E-site tRNA.

spinqualitylabelsall models E. coli ribosome recycling factor complex with decyloxy-methanol and Hg+2 ion (PDB code 1ek8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of ribosome recycling factor3D Structures of ribosome recycling factor

Updated on 07-July-2015

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• Ribosome recycling factor
  • 1dd5 – RRF – Thermotoga maritima
    
  • 1eh1 – TtRRF – Thermus thermophilus
    
  • 1ek8 – EcRRF – Escherichia coli
    
  • 1ise – EcRRF (mutant)
    
  • 1ge9 – RRF – Aquifex aeolicus
    
  • 1is1 – RRF – Vibrio parahaemolyticus
    
  • 1wqf, 1wqg, 1wqh, 4kdd – MtRRF - Mycobacterium tuberculosis
    
  • 1kb2, 4kb4, 4kc6, 4kaw – MtRRF (mutant)
    
  • 4gfq – RRF – Bacillus anthracis
    
  • 1wih – RRF mitochondrial domain II – mouse - NMR
    
• Ribosome recycling factor in the ribosome
  • 4v54, 4v55, 4v5y, 4v9c, 4v9d – EcRRF + part of 50S ribosome
    
  • 1t1m, 1zn1 – EcRRF + part of 70S ribosome – Cryo-EM
    
  • 1zn0, 2rdo – EcRRF + part of 50S ribosome – Cryo-EM
    
  • 3j0d, 3j0e – TtRRF + part of Ec50S ribosome – Cryo-EM
    
  • 4v5a – TtRRF + part of 70S ribosome
    
  • 1y69 – RRF + part of 50S ribosome – Deinococcus radiodurans