Sequestosome: Difference between revisions
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== Function == | == Function == | ||
'''Sequestosome''' (SQS) or '''p62''', is required for the formation and autophagic degredation of polyubiquitin-containg bodies. SQS may regulate signaling cascades through ubiquitination<ref>PMID:15340068</ref>. | |||
== Structural highlights == | |||
SQS is a multi-domain protein. SQS domain structure includes: <br /> | SQS is a multi-domain protein. SQS domain structure includes: <br /> | ||
PB1 domain which contains Phox and Berm1<br /> | PB1 domain which contains Phox and Berm1<br /> | ||
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LIR – interaction region<br /> | LIR – interaction region<br /> | ||
UBA – ubiquitin association domain. | UBA – ubiquitin association domain. | ||
== Relevance == | == Relevance == | ||
SQS is associated with fibrillary tangles in Alzheimer disease<ref>PMID:22138392</ref>. | |||
==3D structures of sequestosome== | ==3D structures of sequestosome== | ||
Revision as of 09:46, 25 August 2016
FunctionSequestosome (SQS) or p62, is required for the formation and autophagic degredation of polyubiquitin-containg bodies. SQS may regulate signaling cascades through ubiquitination[1]. Structural highlightsSQS is a multi-domain protein. SQS domain structure includes: PB1 domain which contains Phox and Berm1 RelevanceSQS is associated with fibrillary tangles in Alzheimer disease[2]. 3D structures of sequestosomeUpdated on 28-May-2025 1q02, 2jy7, 2jy8, 2k0b, 2knv – SQS UBA domain – human - NMR 3b0f – mSQS UBA domain – mouse
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ReferencesReferences
- ↑ Seibenhener ML, Babu JR, Geetha T, Wong HC, Krishna NR, Wooten MW. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol. 2004 Sep;24(18):8055-68. PMID:15340068 doi:10.1128/MCB.24.18.8055-8068.2004
- ↑ Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2012 Jan;96(1):87-95. doi: 10.1016/j.pneurobio.2011.11.005. Epub , 2011 Nov 22. PMID:22138392 doi:http://dx.doi.org/10.1016/j.pneurobio.2011.11.005