5bo8: Difference between revisions

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'''Unreleased structure'''
==Structure of human sialyltransferase ST8SiaIII==
 
<StructureSection load='5bo8' size='340' side='right' caption='[[5bo8]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
The entry 5bo8 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5bo8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BO8 FirstGlance]. <br>
Authors: Volkers, G., Worrall, L., Strynadka, N.C.S.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bo6|5bo6]], [[5bo7|5bo7]], [[5bo9|5bo9]]</td></tr>
Description: Structure of native Glycosyltransferase
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bo8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bo8 RCSB], [http://www.ebi.ac.uk/pdbsum/5bo8 PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Strynadka, N.C.S]]
== Function ==
[[http://www.uniprot.org/uniprot/SIA8C_HUMAN SIA8C_HUMAN]] May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.<ref>PMID:10766765</ref> <ref>PMID:9826427</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Strynadka, N C.J]]
[[Category: Volkers, G]]
[[Category: Worrall, L]]
[[Category: Worrall, L]]
[[Category: Volkers, G]]
[[Category: Sialyltransferase]]
[[Category: Transferase]]

Revision as of 16:39, 15 July 2015

Structure of human sialyltransferase ST8SiaIIIStructure of human sialyltransferase ST8SiaIII

Structural highlights

5bo8 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[SIA8C_HUMAN] May transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid.[1] [2]

References

  1. ↑ Angata K, Suzuki M, McAuliffe J, Ding Y, Hindsgaul O, Fukuda M. Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. J Biol Chem. 2000 Jun 16;275(24):18594-601. PMID:10766765 doi:http://dx.doi.org/10.1074/jbc.M910204199
  2. ↑ Lee YC, Kim YJ, Lee KY, Kim KS, Kim BU, Kim HN, Kim CH, Do SI. Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1, 4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III). Arch Biochem Biophys. 1998 Dec 1;360(1):41-6. PMID:9826427 doi:http://dx.doi.org/10.1006/abbi.1998.0909

5bo8, resolution 2.70Å

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