4zw1: Difference between revisions

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-'''Unreleased structure'''
-The entry 4zw1 is ON HOLD
+==Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer==
+<StructureSection load='4zw1' size='340' side='right' caption='[[4zw1]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-Authors: Liu, B., Zhang, S., Guo, M., Tian, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4zw1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZW1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZW1 FirstGlance]. <br>
-Description: Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4V1:2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-7-METHYL-5,6,7,8-TETRAHYDROPYRIDO[4,3 4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>4V1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zw1 OCA], [http://pdbe.org/4zw1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zw1 RCSB], [http://www.ebi.ac.uk/pdbsum/4zw1 PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Guo, M]]
-[[Category: Zhang, S]]
 [[Category: Liu, B]]
 [[Category: Tian, M]]
+[[Category: Zhang, S]]
+[[Category: Chromatin reader protein]]
+[[Category: Inhibitor]]
+[[Category: Transcription regulation]]
+[[Category: Transcription-inhibitor complex]]