4ztg: Difference between revisions

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-'''Unreleased structure'''
+==Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121==
+<StructureSection load='4ztg' size='340' side='right' caption='[[4ztg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-The entry 4ztg is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>
-Authors: Kirchdoerfer, R.N., Abelson, D.M., Saphire, E.O.
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zta|4zta]], [[4zti|4zti]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [http://www.ebi.ac.uk/pdbsum/4ztg PDBsum]</span></td></tr>
-Description: Ebola virus nucleoprotein bound to VP35 chaperoning peptide P202121
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Saphire, E.O]]
+[[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
-[[Category: Kirchdoerfer, R.N]]
+== References ==
-[[Category: Abelson, D.M]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Abelson, D M]]
+[[Category: Kirchdoerfer, R N]]
+[[Category: Saphire, E O]]
+[[Category: Chaperone]]
+[[Category: Nucleoprotein]]
+[[Category: Rna-bindng]]