Plectin: Difference between revisions
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<Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= ' | <Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '> | ||
'''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3). For more details see [[Group:MUZIC:Plectin]]. | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3). | ||
For more details see [[Group:MUZIC:Plectin]]. | |||
==3D structures of plectin== | ==3D structures of plectin== | ||
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[[4q57]] - hPCN actin-binding domain + calmodulin N terminal<br /> | [[4q57]] - hPCN actin-binding domain + calmodulin N terminal<br /> | ||
== References == | |||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:16, 5 July 2016
<Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain 1sh6' scene= '>
Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure [1]. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).
For more details see Group:MUZIC:Plectin.
3D structures of plectin3D structures of plectin
Updated on 05-July-2016
1mb8, 4q59 – hPCN actin-binding domain – human
1sh5, 1sh6 - PCN actin-binding domain – mouse
3pdy, 3pe0 - hPCN plakin domain
2odu, 2odv – hPCN plakin domain (mutant)
4gdo – hPCN rod domain
3f7p, 4q58 - hPCN actin-binding domain + integrin β4 residues 1126-1370
4q57 - hPCN actin-binding domain + calmodulin N terminal