4xk4: Difference between revisions

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'''Unreleased structure'''
==E. coli transcriptional regulator RUTR with dihydrouracil==
 
<StructureSection load='4xk4' size='340' side='right' caption='[[4xk4]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
The entry 4xk4 is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4xk4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XK4 FirstGlance]. <br>
Authors: Shumilin, I.A., Cooper, D.R., Shabalin, I.G., Grabowski, M., Almo, S.C., Minor, W., New York Structural Genomics Research Consortium (NYSGRC)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUC:DIHYDROPYRIMIDINE-2,4(1H,3H)-DIONE'>DUC</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jyk|4jyk]]</td></tr>
Description: E. coli transcriptional regulator RUTR with dihydrouracil
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4xk4 PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Almo, S.C]]
== Function ==
[[Category: Shumilin, I.A]]
[[http://www.uniprot.org/uniprot/RUTR_ECOLI RUTR_ECOLI]] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).<ref>PMID:16540542</ref> <ref>PMID:17919280</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Almo, S C]]
[[Category: Cooper, D R]]
[[Category: Grabowski, M]]
[[Category: Minor, W]]
[[Category: Minor, W]]
[[Category: Shabalin, I.G]]
[[Category: Structural genomic]]
[[Category: New York Structural Genomics Research Consortium (Nysgrc)]]
[[Category: Shabalin, I G]]
[[Category: Grabowski, M]]
[[Category: Shumilin, I A]]
[[Category: Cooper, D.R]]
[[Category: Helix-turn-helix]]
[[Category: Nysgrc]]
[[Category: Psi-biology]]
[[Category: Transcription regulator]]
[[Category: Transcriptional regulator]]

Revision as of 15:25, 13 May 2015

E. coli transcriptional regulator RUTR with dihydrouracilE. coli transcriptional regulator RUTR with dihydrouracil

Structural highlights

4xk4 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[RUTR_ECOLI] Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX).[1] [2]

References

  1. ↑ Loh KD, Gyaneshwar P, Markenscoff Papadimitriou E, Fong R, Kim KS, Parales R, Zhou Z, Inwood W, Kustu S. A previously undescribed pathway for pyrimidine catabolism. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5114-9. Epub 2006 Mar 15. PMID:16540542 doi:0600521103
  2. ↑ Shimada T, Hirao K, Kori A, Yamamoto K, Ishihama A. RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimidines. Mol Microbiol. 2007 Nov;66(3):744-57. Epub 2007 Oct 5. PMID:17919280 doi:10.1111/j.1365-2958.2007.05954.x

4xk4, resolution 2.27Å

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