4xgm: Difference between revisions

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'''Unreleased structure'''
==Structure of the nuclease subunit of human mitochondrial RNase P (MRPP3) at 1.98A==
 
<StructureSection load='4xgm' size='340' side='right' caption='[[4xgm]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
The entry 4xgm is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4xgm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XGM FirstGlance]. <br>
Authors: Reinhard, L., Sridhara, S., Hallberg, B.M.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] </span></td></tr>
Description: Structure of the nuclease subunit of human mitochondrial RNase P at 1.98A
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xgm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xgm RCSB], [http://www.ebi.ac.uk/pdbsum/4xgm PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Hallberg, B.M]]
== Function ==
[[http://www.uniprot.org/uniprot/MRRP3_HUMAN MRRP3_HUMAN]] Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends.<ref>PMID:18984158</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ribonuclease P]]
[[Category: Hallberg, B M]]
[[Category: Reinhard, L]]
[[Category: Sridhara, S]]
[[Category: Sridhara, S]]
[[Category: Reinhard, L]]
[[Category: Hydrolase]]
[[Category: Metallonuclease]]
[[Category: Mitochondria]]
[[Category: Ppr domain]]
[[Category: Rnase p]]
[[Category: Zinc binding domain]]

Revision as of 15:25, 13 May 2015

Structure of the nuclease subunit of human mitochondrial RNase P (MRPP3) at 1.98AStructure of the nuclease subunit of human mitochondrial RNase P (MRPP3) at 1.98A

Structural highlights

4xgm is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Ribonuclease P, with EC number 3.1.26.5
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[MRRP3_HUMAN] Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends.[1]

References

  1. ↑ Holzmann J, Frank P, Loffler E, Bennett KL, Gerner C, Rossmanith W. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell. 2008 Oct 31;135(3):462-74. PMID:18984158 doi:S0092-8674(08)01135-5

4xgm, resolution 1.98Å

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