5a0c: Difference between revisions

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'''Unreleased structure'''
==Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor==
 
<StructureSection load='5a0c' size='340' side='right' caption='[[5a0c]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
The entry 5a0c is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5a0c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0C FirstGlance]. <br>
Authors: vonNussbaum, F., Li, V.M.-J., Allerheiligen, S., Anlauf, S., Baerfacker, L., Bechem, M., Delbeck, M., Fitzgerald, M.F., Gerisch, M., Gielen-Haertwig, H., Haning, H., Karthaus, D., Lang, D., Lustig, K., Meibom, D., Mittendorf, J., Rosentreter, U., Schaefer, M., Schaefer, S., Schamberger, J., Telan, L.A., Tersteegen, A.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JJV:(6S)-6-(4-CYANO-2-METHYLSULFONYL-PHENYL)-4-METHYL-2-OXIDANYLIDENE-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE'>JJV</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=XPE:3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL'>XPE</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a09|5a09]], [[5a0a|5a0a]], [[5a0b|5a0b]]</td></tr>
Description: Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a0c RCSB], [http://www.ebi.ac.uk/pdbsum/5a0c PDBsum]</span></td></tr>
[[Category: Schamberger, J]]
</table>
[[Category: Mittendorf, J]]
== Disease ==
[[Category: Karthaus, D]]
[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[http://omim.org/entry/162800 162800]]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref>  Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[http://omim.org/entry/202700 202700]]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref> 
[[Category: Li, V.M.-J]]
== Function ==
[[Category: Tersteegen, A]]
[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref> 
[[Category: Lustig, K]]
== References ==
[[Category: Haning, H]]
<references/>
[[Category: Baerfacker, L]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Leukocyte elastase]]
[[Category: Allerheiligen, S]]
[[Category: Allerheiligen, S]]
[[Category: Fitzgerald, M.F]]
[[Category: Anlauf, S]]
[[Category: Anlauf, S]]
[[Category: Telan, L.A]]
[[Category: Baerfacker, L]]
[[Category: Schaefer, M]]
[[Category: Bechem, M]]
[[Category: Bechem, M]]
[[Category: Delbeck, M]]
[[Category: Delbeck, M]]
[[Category: Fitzgerald, M F]]
[[Category: Gerisch, M]]
[[Category: Gielen-Haertwig, H]]
[[Category: Haning, H]]
[[Category: Karthaus, D]]
[[Category: Lang, D]]
[[Category: Lang, D]]
[[Category: Gielen-Haertwig, H]]
[[Category: Li, V M.J]]
[[Category: Gerisch, M]]
[[Category: Lustig, K]]
[[Category: Vonnussbaum, F]]
[[Category: Schaefer, S]]
[[Category: Meibom, D]]
[[Category: Meibom, D]]
[[Category: Mittendorf, J]]
[[Category: Rosentreter, U]]
[[Category: Rosentreter, U]]
[[Category: Schaefer, M]]
[[Category: Schaefer, S]]
[[Category: Schamberger, J]]
[[Category: Telan, L A]]
[[Category: Tersteegen, A]]
[[Category: VonNussbaum, F]]
[[Category: Hydrolase]]
[[Category: Hydrolase- inhibitor complex]]
[[Category: Protease]]
[[Category: Trypsin family fold]]

Revision as of 15:27, 20 August 2015

Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitorCrystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

Structural highlights

5a0c is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Activity:Leukocyte elastase, with EC number 3.4.21.37
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[ELNE_HUMAN] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.[1] [2] Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:202700]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.[3]

Function

[ELNE_HUMAN] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.[4]

References

  1. ↑ Duan Z, Li FQ, Wechsler J, Meade-White K, Williams K, Benson KF, Horwitz M. A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia. Mol Cell Biol. 2004 Jan;24(1):58-70. PMID:14673143
  2. ↑ Horwitz M, Benson KF, Person RE, Aprikyan AG, Dale DC. Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat Genet. 1999 Dec;23(4):433-6. PMID:10581030 doi:10.1038/70544
  3. ↑ Germeshausen M, Zeidler C, Stuhrmann M, Lanciotti M, Ballmaier M, Welte K. Digenic mutations in severe congenital neutropenia. Haematologica. 2010 Jul;95(7):1207-10. doi: 10.3324/haematol.2009.017665. Epub, 2010 Mar 10. PMID:20220065 doi:10.3324/haematol.2009.017665
  4. ↑ Tralau T, Meyer-Hoffert U, Schroder JM, Wiedow O. Human leukocyte elastase and cathepsin G are specific inhibitors of C5a-dependent neutrophil enzyme release and chemotaxis. Exp Dermatol. 2004 May;13(5):316-25. PMID:15140022 doi:10.1111/j.0906-6705.2004.00145.x

5a0c, resolution 2.10Å

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