Sandbox Reserved 1072: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Introduction== | ==Introduction== | ||
[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium Tuberculosis''] [http://en.wikipedia.org/wiki/Catalase-peroxidase Catalase Peroxidase] (''mt''CP) is a <scene name='69/694238/Homodimer/1'>homodimer</scene> with each [http://en.wikipedia.org/wiki/Monomer monomer] consisting of two [http://en.wikipedia.org/wiki/Protein_domain domains]. The overall structure is stabilized by 703 water molecules. | [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium Tuberculosis''] [http://en.wikipedia.org/wiki/Catalase-peroxidase Catalase Peroxidase] (''mt''CP) is a <scene name='69/694238/Homodimer/1'>homodimer</scene> with each [http://en.wikipedia.org/wiki/Monomer monomer] consisting of two [http://en.wikipedia.org/wiki/Protein_domain domains]. The overall structure is stabilized by 703 <scene name='69/694239/Water_molecules/1'>water molecules</scene>. | ||
| Line 17: | Line 17: | ||
<scene name='69/694238/N_terminus/5'>N terminal</scene> does. The [http://en.wikipedia.org/wiki/Active_site active site] is therefore located within the N-terminal domain. The two monomers interact through an interlocking hook formed by the N-terminal domains that stabilizes the formation of the dimer <ref name="one">PMID: 1523184</ref>. | <scene name='69/694238/N_terminus/5'>N terminal</scene> does. The [http://en.wikipedia.org/wiki/Active_site active site] is therefore located within the N-terminal domain. The two monomers interact through an interlocking hook formed by the N-terminal domains that stabilizes the formation of the dimer <ref name="one">PMID: 1523184</ref>. | ||
The N-terminal <scene name='69/694238/N_terminus/2'>hook</scene> is formed through hydrophobic | The N-terminal <scene name='69/694238/N_terminus/2'>hook</scene> is formed through hydrophobic interactions between <scene name='69/694238/N_terminus/6'>residues Tyr-28 and Tyr-197 and residues Trp-38 and Trp-204</scene>. This interlocking loop region is also found in similar conformations of other catalase peroxidase structures such as: [http://www.proteopedia.org/wiki/index.php/1itk ''hm''CP] and ''bp''CP. | ||
===Active Site=== | ===Active Site=== | ||