Hemolysin: Difference between revisions
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{{STRUCTURE_7ahl| PDB=7ahl | SIZE=400| SCENE= |right|CAPTION=α-hemolysin heptamer, [[7ahl]] }} | {{STRUCTURE_7ahl| PDB=7ahl | SIZE=400| SCENE= |right|CAPTION=α-hemolysin heptamer, [[7ahl]] }} | ||
'''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells. | '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells. Hemolysin from the bacterium ''Clostridium'' are called '''alpha-toxin''' (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C. | ||
See details for α-hemolysin in [[Pore forming toxin, α-hemolysin]]. | See details for α-hemolysin in [[Pore forming toxin, α-hemolysin]]. | ||
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**[[1mt0]] – EcHL B ATP-binding domain<br /> | **[[1mt0]] – EcHL B ATP-binding domain<br /> | ||
**[[2oai]], [[2r8d]] – HL corc_hlyc domain – ''Xylella fastidiosa''<br /> | **[[2oai]], [[2r8d]] – HL corc_hlyc domain – ''Xylella fastidiosa''<br /> | ||
**[[2r2z]] – HL residues 346-435 – ''Enterococcus faecalis'' | **[[2r2z]] – HL residues 346-435 – ''Enterococcus faecalis''<br /> | ||
*Alpha-toxin | |||
**[[2wxt]], [[1ca1]] - CpAT + Cd + Zn – ''Clostridium perfringens''<br /> | |||
**[[1qm6]], [[1gyg]], [[1kho]] - CpAT + Zn <br /> | |||
**[[2wy6]], [[2wxu]] – CpAT (mutant) + Ca + Cd + Zn<br /> | |||
**[[1qmd]] - CpAT + Ca + Zn<br /> | |||
**[[1olp]] - AT + Ca + Zn – ''Clostridium absonum''<br /> | |||
**[[2vk9]] - AT – ''Clostridium novyi''<br /> | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||