2v01: Difference between revisions

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OCA

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 |PDB= 2v01 |SIZE=350|CAPTION= <scene name='initialview01'>2v01</scene>, resolution 2.15&Aring;
 |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+A'>AC1</scene>
-|LIGAND= <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
+|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>
 |ACTIVITY=
 |GENE=
+|DOMAIN=
+|RELATEDENTRY=[[1aji|1AJI]], [[1cdl|1CDL]], [[1cll|1CLL]], [[1ctr|1CTR]], [[1iwq|1IWQ]], [[1j7o|1J7O]], [[1j7p|1J7P]], [[1k90|1K90]], [[1k93|1K93]], [[1l7z|1L7Z]], [[1lvc|1LVC]], [[1nkf|1NKF]], [[1pk0|1PK0]], [[1s26|1S26]], [[1sk6|1SK6]], [[1sw8|1SW8]], [[1wrz|1WRZ]], [[1xfu|1XFU]], [[1xfv|1XFV]], [[1xfw|1XFW]], [[1xfx|1XFX]], [[1xfy|1XFY]], [[1xfz|1XFZ]], [[1y6w|1Y6W]], [[1yr5|1YR5]], [[1yrt|1YRT]], [[1yru|1YRU]], [[1zot|1ZOT]], [[2be6|2BE6]], [[2f3y|2F3Y]], [[2f3z|2F3Z]], [[2v02|2V02]]
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v01 OCA], [http://www.ebi.ac.uk/pdbsum/2v01 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v01 RCSB]</span>
 }}
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 ==Overview==
 Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.
-==Disease==
-Known diseases associated with this structure: Cavernous malformations of CNS and retina OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604214 604214]], Cerebral cavernous malformations-1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604214 604214]], Hyperkeratotic cutaneous capillary-venous malformations associated with cerebral capillary malformations OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604214 604214]], Leukemia, acute T-cell lymphoblastic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603025 603025]], Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603025 603025]]
 ==About this Structure==
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 [[Category: Kursula, P.]]
 [[Category: Majava, V.]]
-[[Category: CA]]
-[[Category: PB]]
 [[Category: acetylation]]
 [[Category: calcium]]
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 [[Category: ubl conjugation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:41:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:48 2008''