4cv8: Difference between revisions

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==MPS1 kinase with 3-aminopyridin-2-one inhibitors==
==MPS1 kinase with 3-aminopyridin-2-one inhibitors==
<StructureSection load='4cv8' size='340' side='right' caption='[[4cv8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4cv8' size='340' side='right' caption='[[4cv8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cv9|4cv9]], [[4cva|4cva]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cv9|4cv9]], [[4cva|4cva]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4cv8 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv8 OCA], [http://pdbe.org/4cv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4cv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cv8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==

Revision as of 20:19, 18 January 2017

MPS1 kinase with 3-aminopyridin-2-one inhibitorsMPS1 kinase with 3-aminopyridin-2-one inhibitors

Structural highlights

4cv8 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Dual-specificity kinase, with EC number 2.7.12.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]

References

  1. ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046

4cv8, resolution 3.00Å

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OCA
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