1euu: Difference between revisions
New page: left|200px<br /> <applet load="1euu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1euu, resolution 2.5Å" /> '''SIALIDASE OR NEURAMI... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1EUU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Micromonospora_viridifaciens Micromonospora viridifaciens]] with GAL and NA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EUU OCA]]. | 1EUU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Micromonospora_viridifaciens Micromonospora viridifaciens]] with GAL and NA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EUU OCA]]. | ||
==Reference== | ==Reference== | ||
The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll., Gaskell A, Crennell S, Taylor G, Structure. 1995 Nov 15;3(11):1197-205. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8591030 8591030] | The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll., Gaskell A, Crennell S, Taylor G, Structure. 1995 Nov 15;3(11):1197-205. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8591030 8591030] | ||
[[Category: Exo-alpha-sialidase]] | |||
[[Category: Micromonospora viridifaciens]] | [[Category: Micromonospora viridifaciens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 22: | Line 23: | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:57:17 2007'' | ||
Revision as of 11:52, 30 October 2007
|
SIALIDASE OR NEURAMINIDASE, LARGE 68KD FORM
OverviewOverview
BACKGROUND: Sialidases, or neuraminidases, have been implicated in the, pathogenesis of many diseases, but are also produced by many, non-pathogenic bacteria. Bacterial sialidases are very variable in size, often possessing domains in addition to the catalytic domain. The, sialidase from the non-pathogenic soil bacterium Micromonospora, viridifaciens is secreted in two forms with molecular weights of 41 kDa or, 68 kDa, depending on the nature of the carbohydrate used to induce, expression. RESULTS: We report here the X-ray crystal structures of the 41, kDa and 68 kDa forms of the sialidase from M. viridifaciens at 1.8 A and, 2.5 A resolution respectively. In addition, we report a complex of the 41, kDa form with an inhibitor at 2.0 A resolution, and a complex of the 68, kDa form with ... [(full description)]
About this StructureAbout this Structure
1EUU is a [Single protein] structure of sequence from [Micromonospora viridifaciens] with GAL and NA as [ligands]. Active as [Exo-alpha-sialidase], with EC number [3.2.1.18]. Structure known Active Site: ACT. Full crystallographic information is available from [OCA].
ReferenceReference
The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll., Gaskell A, Crennell S, Taylor G, Structure. 1995 Nov 15;3(11):1197-205. PMID:8591030
Page seeded by OCA on Tue Oct 30 10:57:17 2007