Fibronectin: Difference between revisions

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[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others.  It is a component of cell adhesion.  It is a dimer of homologous monomers linked by S-S bond.  Each monomer contains 3 types of modules: FnI, FnII and FnIII.  Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment  ([[1fbr]]).
[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others.  It is a component of cell adhesion.  It is a dimer of homologous monomers linked by S-S bond.  Each monomer contains 3 types of modules: FnI, FnII and FnIII.  Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD).  


== 3D Structures of Fibronectin ==
== 3D Structures of Fibronectin ==

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Alexander Berchansky, Michal Harel